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Duloxetine hydrochloride nitrite [Ion Chromatography Technical Data]

Measurement of nitrite in duloxetine hydrochloride API by ion chromatography.

Duloxetine hydrochloride is an active pharmaceutical ingredient (API) for the treatment of depression and other neurological disorders. This technical document presents the analysis of nitrite in duloxetine hydrochloride using ion chromatography (IC) with a Metrosep A Supp 10 column equipped with direct UV/VIS detection at 215 nm.

Company：メトロームジャパン本社
Price：Other

Ion Chromatography
Pharmaceutical Intermediates
Pharmaceutical materials and carriers

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Measurement of nitrite in hypromellose [Ion Chromatography Technical Document]

Measurement of nitrite in hydroxypropyl methylcellulose by ion chromatography.

The presence of carcinogenic nitrosamines in pharmaceuticals poses a threat to patient safety. By controlling the concentration of nitrites in drugs and processes, the formation of nitrosamines can be prevented, making it essential to have a highly sensitive method for analyzing nitrites in pharmaceuticals and their raw materials. In many cases, dimethylamine is used in the synthesis of various drugs. Under acidic conditions, it reacts with nitrites to form nitrosamines. This also applies to the production of hydroxypropyl methylcellulose (HPMC), a common excipient. This technical document introduces the quantification of nitrites in hydroxypropyl methylcellulose using ion chromatography (IC) with direct UV/VIS detection.